Korean hemorrhagic fever (KHF) is a benign benign diasease caused by Hantaan virus. Generally, KHF has a benign course though severe complications have been reported. There are rare reports of KHF complicated by panhypopituitarism and central
diabetes
insipidus in spite of autopsy findings which show coagulation necrosis of anterior pituitary gland in almost all cases.
In our case, the patient suffered from polyuria, with a daily urine product of 7 L, and general weakness after 50 th day of admission. The clinical findings, together with combined pituitary function test, water deprivation test, and hypoplastie
change
of pituitary gland in MRF verified panhypopituitarism and partial central diabets insipidus. Other reasonable explanation for the development of the diagnosis could not be found. The diagnosis of KHF was verified by ahigh titers of antibody
against
Hantaan virus in patient's serum. Hormonal substitution therapy with prednisone, thyroxine, and desmopresin was started. The clinical picture became normalized, with increased blood pressure, dereased urine output, and regained strength.
In conclusion, the course of KHF is usually mild, but seriously complicated case may occur. Clinical and hormonal follow up examination might there fore be indicated in patient who had a serious course of KHF.
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